Scientometric and patentometric analyses to determine the knowledge landscape in innovative technologies: The case of 3D bioprinting.

This research proposes an innovative data model to determine the landscape of emerging technologies.

It is based on a competitive technology intelligence methodology that incorporates the assessment of scientific publications and patent analysis production, and is further supported by experts’ feedback. It enables the definition of the growth rate of scientific and technological output in terms of the top countries, institutions and journals producing knowledge within the field as well as the identification of main areas of research and development by analyzing the International Patent Classification codes including keyword clusterization and co-occurrence of patent assignees and patent codes.

This model was applied to the evolving domain of 3D bioprinting. Scientific documents from the Scopus and Web of Science databases, along with patents from 27 authorities and 140 countries, were retrieved. In total, 4782 scientific publications and 706 patents were identified from 2000 to mid-2016.

The number of scientific documents published and patents in the last five years showed an annual average growth of 20% and 40%, respectively. Results indicate that the most prolific nations and institutions publishing on 3D bioprinting are the USA and China, including the Massachusetts Institute of Technology (USA), Nanyang Technological University (Singapore) and Tsinghua University (China), respectively. Biomaterials and Biofabrication are the predominant journals.

The most prolific patenting countries are China and the USA; while Organovo Holdings Inc. (USA) and Tsinghua University (China) are the institutions leading. International Patent Classification codes reveal that most 3D bioprinting inventions intended for medical purposes apply porous or cellular materials or biologically active materials.

FeLV | AG20-0281-Z

AG20-0281-Z 0.1 mg
EUR 516
Description:

FeLV ; AG20-0281-Z ; Immunology Consultants Laboratory

Species Reactivity: p27

Format: Unconjugated AP

Product Type: Protein Standard

Source: E.coli

FIPV N | AG20-0344-Z

AG20-0344-Z 0.1 mg
EUR 516
Description:

FIPV N ; AG20-0344-Z ; Immunology Consultants Laboratory

Species Reactivity: FIPVN

Format: Unconjugated AP

Product Type: Protein Standard

Source: E.coli

Purified CHO MMP-19 Protein | AG65-0424-01-Z

AG65-0424-01-Z 0.1 mg
EUR 894
Description:

Purified CHO MMP-19 Protein ; AG65-0424-01-Z ; Immunology Consultants Laboratory

Species Reactivity: CHO (S cell line)

Format: Unconjugated AP

Product Type: Protein Standard

Source: N/A

AG-14361

27602-1 5 mg
EUR 205
Description: AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM. It is at least 1000-fold more potent than the benzamides. AG14361 treatment before irradiation statistically significantly increases the sensitivity to radiation therapy. AG14361 enhances the growth-inhibitory and cytotoxic effects of topoisomerase I poisons and increases the persistence of camptothecin-induced DNA single-strand breaks.

AG-14361

27602-2 10 mg
EUR 360
Description: AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM. It is at least 1000-fold more potent than the benzamides. AG14361 treatment before irradiation statistically significantly increases the sensitivity to radiation therapy. AG14361 enhances the growth-inhibitory and cytotoxic effects of topoisomerase I poisons and increases the persistence of camptothecin-induced DNA single-strand breaks.

AG-14361

27602-3 50 mg
EUR 825
Description: AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM. It is at least 1000-fold more potent than the benzamides. AG14361 treatment before irradiation statistically significantly increases the sensitivity to radiation therapy. AG14361 enhances the growth-inhibitory and cytotoxic effects of topoisomerase I poisons and increases the persistence of camptothecin-induced DNA single-strand breaks.

AG14361

401020 1.0mg
EUR 215

AG14361

E1KS2178 10mg
EUR 1118.4

AG-14361

B2175-25 each
EUR 907.2

AG-14361

A4158-10 10 mg
EUR 184
Description: Potent PARP1 inhibitor

AG-14361

A4158-100 100 mg
EUR 792
Description: Potent PARP1 inhibitor

AG-14361

A4158-5 5 mg
EUR 96
Description: Potent PARP1 inhibitor

AG-14361

A4158-5.1 10 mM (in 1mL DMSO)
EUR 123
Description: Potent PARP1 inhibitor

AG-14361

A4158-50 50 mg
EUR 544
Description: Potent PARP1 inhibitor

AG-17724

564489 5.0mg
EUR 310

AG-13958

GW6755-1 1
EUR 450.8

AG-13958

GW6755-10 10
EUR 1291.7

AG-13958

GW6755-5 5
EUR 855.4

AG14361

HY-12032 50mg
EUR 1341.6

AG-13958

HY-15492 100mg
EUR 5156.4

AG-13958

T7493-10mg 10mg Ask for price
Description: AG-13958

AG-13958

T7493-1g 1g Ask for price
Description: AG-13958

AG-13958

T7493-1mg 1mg Ask for price
Description: AG-13958

AG-13958

T7493-50mg 50mg Ask for price
Description: AG-13958

AG-13958

T7493-5mg 5mg Ask for price
Description: AG-13958

AG14361

T6339-10mg 10mg Ask for price
Description: AG14361

AG14361

T6339-1g 1g Ask for price
Description: AG14361

AG14361

T6339-1mg 1mg Ask for price
Description: AG14361

AG14361

T6339-50mg 50mg Ask for price
Description: AG14361

AG14361

T6339-5mg 5mg Ask for price
Description: AG14361

Purified Annexin A5 Protein | AG65-0425-01-Z

AG65-0425-01-Z 0.1 mg
EUR 364
Description:

Purified Annexin A5 Protein ; AG65-0425-01-Z ; Immunology Consultants Laboratory

Host: CHO

Format: Unconjugated AP

Product Type: Primary Antibody

Antibody Clonality: Polyclonal

Axitinib (AG-013736)

1581-25 each
EUR 464.4

Axitinib (AG-013736)

1581-5 each
EUR 229.2

AG-014699 phosphate

2890-1 each
EUR 157.2

AG-014699 phosphate

2890-5 each
EUR 444

Purified CHO Legumain Protein | AG65-0423-01-Z

AG65-0423-01-Z 0.1 mg
EUR 894
Description:

Purified CHO Legumain Protein ; AG65-0423-01-Z ; Immunology Consultants Laboratory

Species Reactivity: CHO (S cell line)

Format: Unconjugated AP

Product Type: Protein Standard

Source: N/A

Purified CHO Nidogen-1 Protein | AG65-0426-01-Z

AG65-0426-01-Z 0.1 mg
EUR 894
Description:

Purified CHO Nidogen-1 Protein ; AG65-0426-01-Z ; Immunology Consultants Laboratory

Species Reactivity: CHO (S cell line)

Format: Unconjugated AP

Product Type: Protein Standard

Source: N/A

AG-014699(PF-01367338)

E1KS1098 5mg
EUR 422.4

Purified GFP | AG45-0205-Z

AG45-0205-Z 0.1 mg
EUR 348
Description:

Purified GFP ; AG45-0205-Z ; Immunology Consultants Laboratory

Species Reactivity: GFP

Format: Unconjugated AP

Product Type: Protein Standard

Source: E.coli

Purified CHO Clusterin Protein | AG65-0075-01-Z

AG65-0075-01-Z 0.1 mg
EUR 894
Description:

Purified CHO Clusterin Protein ; AG65-0075-01-Z ; Immunology Consultants Laboratory

Species Reactivity: CHO (S cell line)

Format: Unconjugated AP

Product Type: Protein Standard

Source: N/A

AG28262 free base

T29706-10mg 10mg Ask for price
Description: AG28262 free base

AG28262 free base

T29706-1g 1g Ask for price
Description: AG28262 free base

AG28262 free base

T29706-1mg 1mg Ask for price
Description: AG28262 free base

AG28262 free base

T29706-50mg 50mg Ask for price
Description: AG28262 free base

AG28262 free base

T29706-5mg 5mg Ask for price
Description: AG28262 free base

Purified Beta 2-Microglobulin Protein | AG65-0041-01-Z

AG65-0041-01-Z 0.1 mg
EUR 894
Description:

Purified Beta 2-Microglobulin Protein ; AG65-0041-01-Z ; Immunology Consultants Laboratory

Species Reactivity: CHO (S cell line)

Format: Unconjugated AP

Product Type: Protein Standard

Source: N/A

Purified CHO GSTp Protein | AG65-0337

AG65-0337 1.0 mg
EUR 6110
Description:

Purified CHO GSTp Protein ; AG65-0337 ; Immunology Consultants Laboratory

Species Reactivity: CHO (S-cell line)

Format: Unconjugated AP

Product Type: Protein Standard

Source: N/A

AG1296

20-abx076758
  • Ask for price
  • Ask for price
  • 25 mg
  • 5 mg

AG-7404

530656 1.0mg
EUR 150

AG-1478

A8357-25 25 mg
EUR 120
Description: EGFR inhibitor,potent and selective

AG-1478

A8357-5 5 mg
EUR 40
Description: EGFR inhibitor,potent and selective

AG-1478

A8357-5.1 10 mM (in 1mL DMSO)
EUR 40
Description: EGFR inhibitor,potent and selective

AG-1478

A8357-50 50 mg
EUR 200
Description: EGFR inhibitor,potent and selective

AG-1296

2376-5 each
EUR 235.2

AG-1478

401019 100.0mg
EUR 450

AG1296

406209 25.0mg
EUR 250

AG1295

406210 10.0mg
EUR 330

AG-1024

406233 5.0mg
EUR 240

AG-1557

407453 25.0mg Ask for price

AG-1557

C5417-10 10 mg
EUR 123
Description: inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase

AG-1557

C5417-25 25 mg
EUR 295
Description: inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase

AG-1557

C5417-5 5 mg
EUR 66
Description: inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase

AG-1557

C5417-50 50 mg
EUR 523
Description: inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase

AG-1295

C5465-10 10 mg
EUR 174
Description: potent and selective inhibitor of PDGF receptor kinase

AG-1295

C5465-25 25 mg
EUR 366
Description: potent and selective inhibitor of PDGF receptor kinase

AG-1295

C5465-5 5 mg
EUR 94
Description: potent and selective inhibitor of PDGF receptor kinase

AG-1024

A2673-10 10 mg
EUR 88
Description: Selective IGF-1R inhibitor

AG-1024

A2673-25 25 mg
EUR 166
Description: Selective IGF-1R inhibitor

AG-1024

A2673-5 5 mg
EUR 48
Description: Selective IGF-1R inhibitor

AG-1024

A2673-5.1 10 mM (in 1mL DMSO)
EUR 55
Description: Selective IGF-1R inhibitor

AG-1295

A425200 100mg
EUR 356
Description: 71897-07-9

AG-1478

HY-13524 50mg
EUR 472.8

AG1024

HY-10253 10mg
EUR 252

AG1296

SIH-426-25MG 25 mg
EUR 443
Description: PDGFR kinase inhibitor

AG1296

SIH-426-5MG 5 mg
EUR 107
Description: PDGFR kinase inhibitor

AG1433

T23660-10mg 10mg Ask for price
Description: AG1433

AG1433

T23660-1g 1g Ask for price
Description: AG1433

AG1433

T23660-1mg 1mg Ask for price
Description: AG1433

AG1433

T23660-50mg 50mg Ask for price
Description: AG1433

AG1433

T23660-5mg 5mg Ask for price
Description: AG1433

AG1024

T2693-10mg 10mg Ask for price
Description: AG1024

AG1024

T2693-1g 1g Ask for price
Description: AG1024

AG1024

T2693-1mg 1mg Ask for price
Description: AG1024

AG1024

T2693-50mg 50mg Ask for price
Description: AG1024

AG1024

T2693-5mg 5mg Ask for price
Description: AG1024

AG-1859

T26571-10mg 10mg Ask for price
Description: AG-1859

AG-1859

T26571-1g 1g Ask for price
Description: AG-1859

AG-1859

T26571-1mg 1mg Ask for price
Description: AG-1859

AG-1859

T26571-50mg 50mg Ask for price
Description: AG-1859

AG-1859

T26571-5mg 5mg Ask for price
Description: AG-1859

AG2034

T26572-10mg 10mg Ask for price
Description: AG2034

AG2034

T26572-1g 1g Ask for price
Description: AG2034

AG2034

T26572-1mg 1mg Ask for price
Description: AG2034

AG2034

T26572-50mg 50mg Ask for price
Description: AG2034

AG2034

T26572-5mg 5mg Ask for price
Description: AG2034

AG-7404

T26574-10mg 10mg Ask for price
Description: AG-7404

AG-7404

T26574-1g 1g Ask for price
Description: AG-7404

AG-7404

T26574-1mg 1mg Ask for price
Description: AG-7404

AG-7404

T26574-50mg 50mg Ask for price
Description: AG-7404

AG-7404

T26574-5mg 5mg Ask for price
Description: AG-7404

AG1557

T2034-10mg 10mg Ask for price
Description: AG1557

AG1557

T2034-1g 1g Ask for price
Description: AG1557

AG1557

T2034-1mg 1mg Ask for price
Description: AG1557

AG1557

T2034-50mg 50mg Ask for price
Description: AG1557

AG1557

T2034-5mg 5mg Ask for price
Description: AG1557

AG-1801

T29703-10mg 10mg Ask for price
Description: AG-1801

AG-1801

T29703-1g 1g Ask for price
Description: AG-1801

AG-1801

T29703-1mg 1mg Ask for price
Description: AG-1801

AG-1801

T29703-50mg 50mg Ask for price
Description: AG-1801

AG-1801

T29703-5mg 5mg Ask for price
Description: AG-1801

AG-1478

T2047-10mg 10mg Ask for price
Description: AG-1478

AG-1478

T2047-1g 1g Ask for price
Description: AG-1478

AG-1478

T2047-1mg 1mg Ask for price
Description: AG-1478

AG-1478

T2047-50mg 50mg Ask for price
Description: AG-1478

AG-1478

T2047-5mg 5mg Ask for price
Description: AG-1478

AG6033

T63605-10mg 10mg Ask for price
Description: AG6033

AG6033

T63605-1g 1g Ask for price
Description: AG6033

AG6033

T63605-1mg 1mg Ask for price
Description: AG6033

AG6033

T63605-50mg 50mg Ask for price
Description: AG6033

AG6033

T63605-5mg 5mg Ask for price
Description: AG6033

AG-1296

abx076758-100l 100 µl
EUR 131.25

AG-1296

abx076758-1ml 1 ml Ask for price

AG-1296

abx076758-200l 200 µl
EUR 362.5

AG-1478

abx282513-100g 100 µg Ask for price

AG-1478

abx282513-20g 20 µg
EUR 118.75

AG-1478

abx282513-50g 50 µg
EUR 237.5

Rucaparib (AG-014699,PF-01367338)

27647-1 5 mg
EUR 140
Description: Rucaparib, also known as AG-014699 or PF-01367338, is an inhibitor of PARP1 with Ki of 1.4 nM.

Rucaparib (AG-014699,PF-01367338)

27647-2 10 mg
EUR 195
Description: Rucaparib, also known as AG-014699 or PF-01367338, is an inhibitor of PARP1 with Ki of 1.4 nM.

Rucaparib (AG-014699,PF-01367338)

27647-3 50 mg
EUR 475
Description: Rucaparib, also known as AG-014699 or PF-01367338, is an inhibitor of PARP1 with Ki of 1.4 nM.

Rucaparib (AG-014699,PF-01367338)

A4156-10 10 mg
EUR 104
Description: Potent PARP inhibitor

Rucaparib (AG-014699,PF-01367338)

A4156-200 200 mg
EUR 680
Description: Potent PARP inhibitor

Rucaparib (AG-014699,PF-01367338)

A4156-5 5 mg
EUR 60
Description: Potent PARP inhibitor

Rucaparib (AG-014699,PF-01367338)

A4156-5.1 10 mM (in 1mL DMSO)
EUR 72
Description: Potent PARP inhibitor

Rucaparib (AG-014699,PF-01367338)

A4156-50 50 mg
EUR 280
Description: Potent PARP inhibitor

Rucaparib (AG-014699,PF-01367338)

A4156-S Evaluation Sample
EUR 22
Description: Potent PARP inhibitor

Dengue NS1 Protein-Type 1 | AG55-0258-Z

AG55-0258-Z 0.1 mg
EUR 364
Description:

Dengue NS1 Protein-Type 1 ; AG55-0258-Z ; Immunology Consultants Laboratory

Species Reactivity: NS1

Format: Unconjugated AP

Product Type: Protein Standard

Source: HEK-293

Dengue NS1 Protein-Type 2 | AG55-0259-Z

AG55-0259-Z 0.1 mg
EUR 364
Description:

Dengue NS1 Protein-Type 2 ; AG55-0259-Z ; Immunology Consultants Laboratory

Species Reactivity: NS1

Format: Unconjugated AP

Product Type: Protein Standard

Source: HEK-293

Dengue NS1 Protein-Type 2 | AG55-0259-Z

AG55-0260-Z 0.1 mg
EUR 364
Description:

Dengue NS1 Protein-Type 3 ; AG55-0260-Z ; Immunology Consultants Laboratory

Species Reactivity: NS1

Format: Unconjugated AP

Product Type: Protein Standard

Source: HEK-293

Dengue NS1 Protein-Type 4 | AG55-0261-Z

AG55-0261-Z 0.1 mg
EUR 364
Description:

Dengue NS1 Protein-Type 4 ; AG55-0261-Z ; Immunology Consultants Laboratory

Species Reactivity: NS1

Format: Unconjugated AP

Product Type: Protein Standard

Source: HEK-293

Purified CHO PLBL2 Protein | AG65-0324

AG65-0324 1.0 mg
EUR 6110
Description:

Purified CHO PLBL2 Protein ; AG65-0324 ; Immunology Consultants Laboratory

Species Reactivity: CHO (3E7 cell line)

Format: Unconjugated AP

Product Type: Protein Standard

Source: N/A

Purified CHO GSTp Protein | AG65-0337-Z

AG65-0337-Z 0.1 mg
EUR 818
Description:

Purified CHO GSTp Protein ; AG65-0337-Z ; Immunology Consultants Laboratory

Species Reactivity: CHO (S-cell line)

Format: Unconjugated AP

Product Type: Protein Standard

Source: N/A

Purified CHO PLBL2 Protein | AG65-0365

AG65-0365 1.0 mg
EUR 6110
Description:

Purified CHO PLBL2 Protein ; AG65-0365 ; Immunology Consultants Laboratory

Species Reactivity: CHO (S cell line)

Format: Unconjugated AP

Product Type: Protein Standard

Source: N/A

AG1478 HCl

563014 10.0mg
EUR 350

AG-1517 HCl

abx076745-100l 100 µl
EUR 143.75

AG-1517 HCl

abx076745-1ml 1 ml Ask for price

AG-1517 HCl

abx076745-200l 200 µl
EUR 387.5

Purified CHO PLBL2 Protein | AG65-0324-Z

AG65-0324-Z 0.1 mg
EUR 818
Description:

Purified CHO PLBL2 Protein ; AG65-0324-Z ; Immunology Consultants Laboratory

Species Reactivity: CHO (3E7 cell line)

Format: Unconjugated AP

Product Type: Protein Standard

Source: N/A

Purified CHO PLBL2 Protein | AG65-0365-Z

AG65-0365-Z 0.1 mg
EUR 818
Description:

Purified CHO PLBL2 Protein ; AG65-0365-Z ; Immunology Consultants Laboratory

Species Reactivity: CHO (S cell line)

Format: Unconjugated AP

Product Type: Protein Standard

Source: N/A

Plasmodium falciparum | AG55-0092-Z

AG55-0092-Z 0.1 mg
EUR 410
Description:

Plasmodium falciparum ; AG55-0092-Z ; Immunology Consultants Laboratory

Species Reactivity: HRP2

Format: Unconjugated AP

Product Type: Protein Standard

Source: E.coli

AG-1812 free base

T29704-10mg 10mg Ask for price
Description: AG-1812 free base

AG-1812 free base

T29704-1g 1g Ask for price
Description: AG-1812 free base

AG-1812 free base

T29704-1mg 1mg Ask for price
Description: AG-1812 free base

AG-1812 free base

T29704-50mg 50mg Ask for price
Description: AG-1812 free base

AG-1812 free base

T29704-5mg 5mg Ask for price
Description: AG-1812 free base

AG-2000 Free Base

T29705-10mg 10mg Ask for price
Description: AG-2000 Free Base

AG-2000 Free Base

T29705-1g 1g Ask for price
Description: AG-2000 Free Base

AG-2000 Free Base

T29705-1mg 1mg Ask for price
Description: AG-2000 Free Base

AG-2000 Free Base

T29705-50mg 50mg Ask for price
Description: AG-2000 Free Base

AG-2000 Free Base

T29705-5mg 5mg Ask for price
Description: AG-2000 Free Base

A630001G21Rik (GFP-tagged) - Mouse RIKEN cDNA A630001G21 gene (A630001G21Rik), (10ug)

MG213122 10 µg Ask for price

Knowledge clusters and expert drivers indicate that there is a research focus on tissue engineering including the fabrication of organs, bioinks and new 3D bioprinting systems. Our model offers a guide to researchers to understand the knowledge production of pioneering technologies, in this case 3D bioprinting.